Luke Engelking, M.D., Ph.D. Associate Dean for Medical Student Research (Interim) Associate Professor School Medical School Department Internal Medicine | Center for Human Nutrition | Molecular Genetics Graduate Programs Cell and Molecular Biology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Luke Engelking, M.D., Ph.D., is an Associate Professor of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Digestive and Liver Diseases. He also serves as the Associate Dean for Medical Student Research. His clinical interests include the treatment of patients with either known or suspected inherited disorders of polyposis and/or colorectal cancer, including Lynch syndrome, Familial Adenomatous Polyposis syndrome, Peutz-Jeghers syndrome, Juvenile Polyposis syndrome, and Cowden syndrome. His suspecialty clinics in genetic gastrointestinal disorders are located in the Simmons Cancer Center's Genetic Cancer Prevention Clinic, Parkland Health and Hospital Systems GI Clinic, and the Digestive and Liver Diseases Clinic. Raised in Houston, Dr. Engelking received a bachelor's degree in biochemistry and genetics from Texas A&M University. He then completed his medical degree and a doctoral degree in biomedical science at UT Southwestern, where he studied cholesterol and lipid metabolism under the tutelage of nobel laureates Michael Brown, M.D., and Joseph Goldstein, M.D. He received internal medicine residency training at Massachusetts General Hospital in Boston, and returned to UT Southwestern for clinical and research fellowships in gastroenterology. He later completed intensive training in genetic cancer risk assessment (GCRA) from the City of Hope and is a certified GCRA specialist. As a postdoctoral researcher, he studied lipid synthesis in the intestine, which is recognized as a key metabolic organ at the center of nutrient homeostasis. He demonstrated that Sterol Response Element-Binding Proteins (SREBPs) are major players in the regulation of intestinal lipid synthesis. A Diplomate of the American Board of Internal Medicine in both internal medicine and gastroenterology, Dr. Engelking joined the UT Southwestern faculty in 2014. His lab investigates lipid metabolic regulation of intestinal epithelial homeostasis and tumorgenesis, supported by major grants from National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Cancer Prevention & Research Institute of Texas (CPRIT). His ultimate goals are to discover new lipid-derived oncometabolites that may be targeted in the fight against colon cancer, and to clarify the links between dietary lipids and intestinal cancers. He is a local leader in clinical trials in colorectal cancer, colon cancer screening, and hereditary GI cancer syndromes. Dr. Engelking is an active member of the American Society for Biochemistry and Molecular Biology, the American Gastroenterological Association, and the Collaborative Group of the Americas on Inherited Colorectal Cancer. Education Medical School UT Southwestern Medical School (2007) Residency Massachusetts General Hospital (2010), Internal Medicine Fellowship UT Southwestern Medical Center (2014), Gastroenterology Research Interest Cholesterol and lipid biology Colon cancer screening Colorectal cancer Inherited Colon Cancer and Polyposis Syndromes, Lynch Syndrome, Familial Adenomatous Polyposis Syndrome SREBP, Scap and Insig Proteins Publications Featured Publications Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity. Zhang Z, Funcke JB, Zi Z, Zhao S, Straub LG, Zhu Y, Zhu Q, Crewe C, An YA, Chen S, Li N, Wang MY, Ghaben AL, Lee C, Gautron L, Engelking LJ, Raj P, Deng Y, Gordillo R, Kusminski CM, Scherer PE, Cell Metab 2021 Jun Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice. Linden AG, Li S, Choi HY, Fang F, Fukasawa M, Uyeda K, Hammer RE, Horton JD, Engelking LJ, Liang G J. Lipid Res. 2018 Jan Scap is required for sterol synthesis and crypt growth in intestinal mucosa. McFarlane MR, Cantoria MJ, Linden AG, January BA, Liang G, Engelking LJ J. Lipid Res. 2015 Apr Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Clin. Invest. 2006 Sep 116 9 2356-65 Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS J. Clin. Invest. 2005 Sep 115 9 2489-98 Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G J. Clin. Invest. 2004 Apr 113 8 1168-75 RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine. Miskelly MG, Lindqvist A, Piccinin E, Hamilton A, Cowan E, Nergård BJ, Del Giudice R, Ngara M, Cataldo LR, Kryvokhyzha D, Volkov P, Engelking L, Artner I, Lagerstedt JO, Eliasson L, Ahlqvist E, Moschetta A, Hedenbro J, Wierup N, Diabetologia 2023 Nov Developmental and extrahepatic physiological functions of SREBP pathway genes in mice. Engelking LJ, Cantoria MJ, Xu Y, Liang G Semin. Cell Dev. Biol. 2017 Jul Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine. Rong S, McDonald J, Engelking L J. Lipid Res. 2017 Jun Hypoxia-inducible factor-1a activates insig-2 transcription for degradation of HMG CoA reductase in the liver. Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA J. Biol. Chem. 2017 Apr Results 1-10 of 14 1 2 Next Last Honors & Awards Disease-Oriented Clinical ScholarUT Southwestern (2014) Distinguished Researcher's AwardPresident's Research Council (2014) Research Scholar in Liver DiseaseNorth American Gilead Sciences (2014) Alpha Omega Alpha Honor Medical SocietyUT Southwestern (2007) Summa cum laudeTexas A&M University (2000) University HonorsTexas A&M University (2000) University Undergraduate Research FellowTexas A&M University (2000) Professional Associations/Affiliations American Gastroenterological Association (2010) American Society for Biochemistry and Molecular Biology (2010) Collaborative Group of the Americas on Inherited Colorectal Cancer (2022)
